| WEEK # | TOPICS | READINGS |
|---|---|---|
| 1 |
Introduction | No Readings |
| 2 |
The effect of age on reproduction in men and women |
Allen, E. G., S. B. Freeman, et al. "Maternal Age and Risk for Trisomy 21 Assessed by the Origin of Chromosome Nondisjunction: A Report from the Atlanta and National Down Syndrome Projects." Human Genetics 125, no. 1 (2009): 41–52. Robertshaw, I., J. Khoury, et al. "The Effect of Paternal Age on Outcome in Assisted Reproductive Technology Using the Ovum Donation Model." Reproductive Sciences 21, no. 5 (2014): 590–93. |
| 3 |
Gonadal stem cells |
Johnson, J., J. Bagley, et al. "Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood." Cell 122, no. 2 (2005): 303–15. Eggan, K., S. Jurga, et al. "Ovulated Oocytes in Adult Mice Derive from Non-circulating Germ Cells." Nature 441, no. 7097 (2006): 1109–114. |
| 4 |
Cryopreservation of human embryos and oocytes |
Trounson, A., and L. Mohr. "Human Pregnancy following Cryopreservation, Thawing and Transfer of an Eight-cell Embryo." Nature 305, no. 5936 (1983): 707–9. Wennerholm, U. B., V. Söderström-Anttila, et al. "Children Born After Cryopreservation of Embryos or Oocytes: A Systematic Review of Outcome Data." Human Reproduction 24, no. 9 (2009): 2158–72. |
| 5 |
Characterization of infertility |
Rosen, Mitchell P., Barbara Sternfeld, et al. "Antral Follicle Count: Absence of Significant Midlife Decline." Fertility and Sterility 94, no. 6 (2010): 2182–185. Oates, R. D., S. Silber, et al. "Clinical Characterization of 42 Oligospermic or Azoospermic Men with Microdeletion of the AZFc Region of the Y Chromosome, and of 18 Children Conceived via ICSI." Human Reproduction 17, no. 11 (2002): 2813–24. |
| 6 |
Sex chromosome constitution and fertility |
Hunt, P. A., C. Worthman, et al. "Germ Cell Loss in the XXY Male Mouse: Altered X-chromosome Dosage Affects Prenatal Development." Molecular Reproduction and Development 49, no. 9 (1998): 101-11. Lin, B., F. Tan, et al. "De Novo Structure Variations of the Y Chromosome in a 47,XXY Female with Ovarian Failure: A Case Report." Cytogenetic and Genome Research 143, no. 4 (2014): 221–4. |
| 7 |
Embryo culture, assessment, selection and transfer |
Rienzi, L., A. Capalbo, et al. "No Evidence of Association Between Blastocyst Aneuploidy and Morphokinetic Assessment in a Selected Population of Poor-prognosis Patients: A Longitudinal Cohort Study." Reproductive Biomedicine Online 30, no. 1 (2015): 57–66. Wells, D., K. Kaur, et al. "Clinical Utilisation of a Rapid Low-pass Whole Genome Sequencing Technique for the Diagnosis of Aneuploidy in Human Embryos Prior to Implantation." Journal of Medical Genetics 51, no. 8 (2014): 553–62. |
| 8 |
Visit to Boston area IVF clinic | No Readings |
| 9 |
Mouse models with abnormal reproductive phenotypes |
Ferguson, L., J. J. How, et al. "The Fate of Spermatogonial Stem Cells in the Cryptorchid Testes of RXFP2 Deficient Mice." PLoS One 8, no. 10 (2013): e77351. Youngren, K. K., D. Coveney, et al. "The Ter Mutation in the Dead End Gene Causes Germ Cell Loss and Testicular Germ Cell Tumours." Nature 435, no. 7040 (2005): 360–64. |
| 10 |
Seminal fluid–more than just a carrier of sperm |
Bromfield, J. J., J. E. Schjenken, et al. "Maternal Tract Factors Contribute to Paternal Seminal Fluid Impact on Metabolic Phenotype in Offspring." Proceedings of the National Academy of Sciences of the United States of America 111, no. 6 (2014): 2200–05. Crawford, G., A. Ray, et al. "The Role of Seminal Plasma for Improved Outcomes During in Vitro Fertilization Treatment: Review of the Literature and Meta-analysis." Human Reproduction Update 21, no. 2 (2015): 275–84. |
| 11 |
Promise and challenges in reprogramming adult cells to gametes |
Hayashi, K., S. Ogushi, et al. "Offspring from Oocytes Derived from in Vitro Primordial Germ Cell-like Cells in Mice." Science 338, no. 6109 (2012): 971–5. Irie, N., L. Weinberger, et al. "SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate." Cell 160, no. 1–2 (2015): 253–68. |
| 12 |
Student paper presentations and discussions | No Readings |