Browsing Chemical and Pharmaceutical Engineering (CPE) by Author "Hatton, T. Alan"
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Aggregation of Synthetic Gene Delivery Vectors Enhance the Cellular Association and Uptake for in vitro Transfection
Simeon, Fritz; Tam, Michael K.C.; Hatton, T. Alan; Too, Heng-Phon (2007-01)Development of safe and efficient synthetic gene delivery vectors is hampered with limited understanding the fundamental correlation of physicochemical properties of the vectors with their biological activities. Five major ... -
Synthesis and Complexation Behavior of Pluronic-b-Poly(acrylic Acid) Copolymer with Doxorubicin
Tian, Y.; Tam, Michael K. C.; Hatton, T. Alan; Bromberg, Lev (2007-01)Poly(acrylic acid) (PAA) was attached on both termini of Pluronic P85 copolymer (EO27PO39EO27)) via atom transfer radical polymerization (ATRP) to produce a novel block copolymer, PAA-b-P85-b-PAA (P85PAA). The P85PAA-DOX ... -
Synthesis and Self-Assembly Behavior of Poly(acrylic Acid)-b-Poly(l-Amino Acid) System
Sinaga, Akasta; Ravi, P.; Hatton, T. Alan; Tam, Michael K. C. (2007-01)The talk will present the synthesis and characterization of a new class of hybrid amphiphilic system between an electrolyte polyacrylic acid (PAA) synthetic segment, and a hydrophobic beta-sheet forming peptide segment, ... -
Understanding the Induced Self-Assembly System Between PEO-b-PAA and Iron
Sondjaja, H. Ronny; Tam, Michael K.C.; Yap, Miranda G.S.; Hatton, T. Alan (2007-01)The induced self-assembly phenomenon between PEO-b-PAA and Fe(II) was investigated. It was revealed that the electrostatic interaction between Fe(II) in the form of green rust (GR²⁺) particles and the COO- groups from the ...