Browsing Chemical and Pharmaceutical Engineering (CPE) by Title

Aggregation of Synthetic Gene Delivery Vectors Enhance the Cellular Association and Uptake for in vitro Transfection

Simeon, Fritz; Tam, Michael K.C.; Hatton, T. Alan; Too, Heng-Phon (2007-01)

Development of safe and efficient synthetic gene delivery vectors is hampered with limited understanding the fundamental correlation of physicochemical properties of the vectors with their biological activities. Five major ...

Biological Routes to Gold Nanoplates

Xie, Jianping; Lee, Jim Yang; Wang, Daniel I.C.; Ting, Yen Peng (2007-01)

Gold nanoplates are promising for optical and electronic applications; but their synthesis is complex, often requiring a seeded growth process or spherical to triangle morphology transformation. We have discovered a ...

DNA Directed Assembly Probe for Detecting DNA-Protein Interaction in Microarray Format

Ng, Jin Kiat; Ajikumar, Parayil Kumaran; Tang, Yew Chung; Stephanopoulos, Gregory; Too, Heng-Phon (2007-01)

Quantifying DNA-protein interaction using DNA microarrays are gaining increasing attention due to their ability to profile specificity of interactions in a high-throughput manner. This paper describes a new approach that ...

Micro-porous Paclitaxel-Loaded PLGA Foams -- a New Implant Material for Controlled Release of Chemotherapeutic Agents

Lee, Lai Yeng; Wang, Chi Hwa; Smith, Kenneth A. (2007-01)

Supercritical gas foaming using CO₂ was used to fabricate blank poly DL lactide-co-glycolide (PLGA) micro-porous foams. Paclitaxel-loaded PLGA foams were also produced for the first time using a modification of the ...

Multivariate Perturbation of a Growth Factor-Cytokine Signalling Network Reveals Complex Systemic Responses in Glioblastoma Cells

Tang, Yew Chung; Wan, Guoqiang; Stephanopoulos, Gregory; Too, Heng-Phon (2007-01)

Glioblastoma cells can evade TRAIL-induced apoptosis through various strategies involving the growth factor-activated MEK–MAPK/ERK and PI3K–Akt/PKB pro-survival signalling cascades. Although these signalling cascades have ...

On the Droplet Formation Process in Electrohydrodynamic Atomization

Lim, Liang Kuang; Xie, Jingwei; Hua, Jinsong; Wang, Chi-Hwa; Smith, Kenneth A. (2007-01)

A novel method of using a secondary electrical field source to control both the spray mode and the droplet size in the electrohydrodynamic atomization process is presented. Size of particles fabricated using the ...

Prediction of Glycerol-Effect on Antigen-Antibody Binding Affinity from Molecular Dynamics Simulations

Vagenende, Vincent; Yap, Miranda G.S.; Trout, Bernhardt L. (2007-01)

Many biological and biotechnological processes are controlled by protein-protein interactions in solution. In order to understand, predict and optimize such processes, it is valuable to understand how additives such as ...

Preparation of DNA-Functionalised CdSe/ZnS Quantum Dots

Pong, Boon Kin; Trout, Bernhardt L.; Lee, Jim Yang (2007-01)

We functionalised core-shell CdSe/ZnS quantum dots (QDots) with short-chain 3-mercaptopropionic acid (3MPA) to render these nanocrystalline semiconductor water-soluble. The ligand-exchange reaction was significantly improved ...

Secondary Flow and Upstream Dynamics in Double Bifurcation Model

Leong, Fong Yew; Smith, Kenneth A.; Wang, Chi-Hwa (2007-01)

Flow behavior in bifurcation models is of great importance to health risk assessments and pulmonary drug delivery. This is particularly true of secondary flow behavior in multi-bifurcation models. Previously, both numerical ...

Simple and Versatile Route to the Synthesis of Anisotropic Bimetallic Core-Shell and Monometallic Hollow Nanostructures: Ag (AgCl)-Pt Core-Shell Nanocubes and Pt Nanoboxes

Tan, Yen Nee; Wang, Daniel I.C.; Lee, Jim Yang (2007-01)

We report herewith a simple and versatile route for the preparation of anisotropic Ag(AgCl)-Pt core-shell nanocubes and Pt nanoboxes. The core-shell nanocubes were first synthesized through the simultaneous reduction method ...

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