This is an archived course. A more recent version may be available at ocw.mit.edu.

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Lecture Notes

SES # TOPICS LECTURERS LECTURE NOTES
I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes
L1 Survey of Clinical Cases of Biomaterials-Tissue Interactions Yannas/Spector Introduction by Spector (PDF)

Introduction by Yannas (PDF)
L2 Tissue Structures, Unit Cell Processes, and Integrins Spector Tools for Understanding the Molecular, Cellular, and Physiological, Bases of the Tissue Response to Implants (PDF)

Introduction: Tissue Types (PDF - 1.7 MB)

Unit Cell Processes (PDF)

Integrins (PDF)
L3 Unit Cell Processes Comprising the Healing Response Spector UCPs in the Healing Environment (PDF)

Formation of Soft Tissue and Bone Around Implants: The Chronic Response to Implants (PDF)
L4 Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs Yannas Irreversible Healing of Extracellular Matrix (PDF)
L5 Biochemistry of the ECM Yannas Naturally Occuring ECMs: Collagen (PDF - 1.1 MB)

Naturally Occuring ECMs: Elastin, PG and GAG, CAM (PDF)
L6 Scaffolds Based on ECM Analogs Used in Organ Synthesis Yannas Synthesis of Biologically Active Scaffolds (Regeneration Templates) (PDF)
L7 Organ Replacement by Induced Regeneration and Tissue Engineering Yannas/Spector Tissue Engineering: Overview (PDF)
L8 Principles and Practice of Tissue Engineering Spector Tissue Engineering: Stem Cells (PDF - 1.5 MB)
E1 Quiz 1    
II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue
L9 Characteristics of the Surfaces of Biomaterials Spector Materials: Bonding and Properties (PDF)

Cell-Matrix Interactions (PDF)

Response to Particles (PDF)
L10 Methodology for the Analysis of Surfaces Spector  
L11 Physicochemical Principles of Protein Adsorption on Solid Surfaces Spector  
L12 Protein/Cell/Tissue-Biomaterials Interactions Spector  
L13 Linear vs. Cooperative Cell-Matrix Interactions Yannas Cell-Matrix Interactions [That Determine Biomaterials Function In Vitro and In Vivo] (PDF)
L14 Cell-Matrix Interactions During Spontaneous Healing Yannas Cell-Matrix Interactions - Part B (PDF)
L15 Contraction-Blocking Theory of Regeneration in Adults Yannas Cell-Matrix Interactions - Part C (PDF)

A Theory of Induced Regeneration in Adults (PDF)
E2 Quiz 2    
III. In Vivo and Clinical Case Studies
L16 Joints and Dental Tissues: Prosthetic Replacement Spector Materials for Joint Replacement (PDF)
L17 Joints and Dental Tissues: Regeneration 1 Spector Biomaterials for Joint Regeneration 1 (PDF)
L18 Joints and Dental Tissues: Regeneration 2 Spector Dental Tissue Regeneration (PDF)

Biomaterials for Joint Regeneration 2 (PDF - 1.2 MB)
L19 Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses Spector  
L20 Rules for Synthesis of Tissues and Organs Yannas Simplest Synthetic Pathways (PDF)
L21 In Vivo Synthesis of Skin Yannas Methodology of Organ Synthesis (PDF)
L22 In Vivo Synthesis of Peripheral Nerves Yannas Conjunctiva Synthesis In Vivo (Regeneration) (PDF)
L23 In Vivo Synthesis of the Conjunctiva and of Kidney Tissue Yannas  
E3 Quiz 3