Readings
Text
Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.
| SES # | TOPICS | TEXT READINGS | ADDITIONAL REFERENCES |
|---|---|---|---|
| I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes | |||
| L1 | Survey of Clinical Cases of Biomaterials-Tissue Interactions | Survey of Clinical Cases of Biomaterials-Tissue Interactions: The Paradigm (PDF) | |
| L2 | Tissue Structures, Unit Cell Processes, and Integrins | Giancotti, F. G., and E. Ruoslahti. "Integrin Signaling." Science 285 (13 Aug 1999): 1028-1032. This paper presents the concept of integrin signaling. Ruoslathi, E., and M. D. Pierschbacher. "New Perspectives in Cell Adhesion: RGD and Integrins." Science 238, no. 4826 (23 Oct 1987): 491-497. This paper describes the discovery of an amino acid sequence that is a ligand for integrins. Working/Operational Definitions (PDF) Tissue Structure/Unit Cell Processes (PDF) | |
| L3 | Unit Cell Processes Comprising the Healing Response | ||
| L4 | Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs | Chapters 1-4 | |
| L5 | Biochemistry of the ECM | Extracellular Matrix Molecules (PDF) | |
| L6 | Scaffolds Based on ECM Analogs Used in Organ Synthesis | Chapter 8 | |
| L7 | Organ Replacement by Induced Regeneration and Tissue Engineering | ||
| L8 | Principles and Practice of Tissue Engineering | ||
| E1 | Quiz 1 | ||
| II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue | |||
| L9 | Characteristics of the Surfaces of Biomaterials | Characteristics of the Surfaces of Biomaterials (PDF) | |
| L10 | Methodology for the Analysis of Surfaces |
Ratner, B. D. "Surface Properties of Biomaterials." In Biomaterials Science. Edited by B. D. Ratner, et. al. Burlington, MA: Academic Press, 1996. ISBN: 9780125824606. Methodology for Chemical Analysis of Surfaces (PDF) | |
| L11 | Physicochemical Principles of Protein Adsorption on Solid Surfaces | Andrade, J. D. "Principles of Protein Adsorption." In Surface and Interfacial Aspects of Biomedical Polymers. Vol. 2. Edited by J. D. Andrade. NY: Plenum Press, 1985. Chinn, J. A., et. al. "Postadsorptive transitions in fibrinogen adsorbed to polyurethanes." Journal of Biomedical Materials Research 26 (1992): 757-778. Rapoza, R. J., and T. A. Horbett. "Postadsorptive transitions in fibrinogen: Influence of polymer properties." Journal of Biomedical Materials Research 24 (1990): 1263-1287. | |
| L12 | Protein/Cell/Tissue-Biomaterials Interactions | ||
| L13 | Linear vs. Cooperative Cell-Matrix Interactions | ||
| L14 | Cell-Matrix Interactions During Spontaneous Healing | Chapter 9 | |
| L15 | Contraction-Blocking Theory of Regeneration in Adults | Chapters 8 and 10 | |
| E2 | Quiz 2 | ||
| III. In Vivo and Clinical Case Studies | |||
| L16 | Joints and Dental Tissues: Prosthetic Replacement | Joints: Regeneration of Bone, Cartilage, Meniscus, Ligament, and Tendon (PDF) | |
| L17 | Joints and Dental Tissues: Regeneration 1 | ||
| L18 | Joints and Dental Tissues: Regeneration 2 | ||
| L19 | Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses | ||
| L20 | Rules for Synthesis of Tissues and Organs | Chapter 7 | |
| L21 | In Vivo Synthesis of Skin | Chapter 5 | |
| L22 | In Vivo Synthesis of Peripheral Nerves | Chapter 6 | |
| L23 | In Vivo Synthesis of the Conjunctiva and of Kidney Tissue | Chapter 8 | |
| E3 | Quiz 3 | ||
