Browsing Molecular Engineering of Biological and Chemical Systems (MEBCS) by Issue Date
Now showing items 1-20 of 106
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Molecular Study of Interactions between Hematopoietic Stem Cells and Stromal Cells
(2002-01)Multipotent hematopoietic stem cells (HSCs) are progenitors of all types of hematopoietic cells, and the efficient isolation and propagation of HSCs will significantly enhance our ability to manage many human disorders ... -
Stabilization of Therapeutic Proteins
(2003-01)We present results of molecular simulations, quantum mechanical calculations, and experimental data aimed towards the rational design of solvent formulations. In particular, we have found that the rate limitation of oxidation ... -
Stability of Granular Materials under Vertical Vibrations
(2003-01)The influence of periodic vibrations on the granular flow of materials is of great interests to scientists and engineers due to both theoretical and practical reasons. In this paper, the stability of a vertically vibrated ... -
Rheological and Thermodynamic Properties of PEO-PPE-PEO and PAA-g-PEO-PPO-PEO System
(2003-01)Rheological and thermodynamic properties of Pluronic F127 copolymer and Pluronic-g-PAA have been studied as a function of temperature and concentration. A combination of rheometry and DSC was employed to examine the gelation ... -
Computational Method for Drug Target Search and Application in Drug Discovery
(2003-01)Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug. A protein structure database is searched to find proteins to which a drug can bind ... -
Activation Ratios For Reconstruction Of Signal Transduction Networks
(2003-01)We have developed a novel framework that can be applied for the analysis of signal transduction networks, both to facilitate reconstruction of the network structure and quantitatively characterize the interaction between ... -
Engineering Mammalian Cells for Improved Recombinant Protein Production
(2003-01)The production of recombinant glycoproteins from mammalian cell cultures requires robust processes that can achieve high protein yield while ensuring the efficacy of these proteins as human therapeutics. We describe two ... -
Quantitative linkage of physiology and gene expression through empirical model construction: an investigation of diabetes
(2003-01)A methodology for the construction of predictive empirical models of physiological characteristics from microarray data is presented. The method, applied here to the study of the development of diabetes and insulin resistance, ... -
Changes in the Overall Extent of Protein Glycosylation by Chinese Hamster Ovary Cells Over the Course of Batch Culture
(2003-01)Glycosylation of recombinant proteins can change during the culture of animal cells. Since lipid-linked oligosaccharides (LLOs) are the carbohydrate donors in N-linked glycosylation, their availability is postulated to ... -
Computer-Aided Drug Target Search
(2003-01)Identification of the unknown targets of drugs, investigative drugs and herbal ingredients is an important task in drug discovery. It can potentially help in several aspects including: (1) determination of unknown therapeutic ... -
Glucose-Sensitive Nanoparticles for Controlled Insulin Delivery
(2003-01)A novel reverse microemulsion (RM) mediated synthesis of glucose-responsive nanoparticles was developed for controlled insulin delivery. Nanoparticles were constructed using a model system comprised of dextran, poly(α-1,6 ... -
Increasing The Odds Of Hit Iidentification By Screening Against Receptor Homologs
(2003-01)Increasing the odds of hit identification in screening is of significance for drug discovery. The odds for finding a hit are closely related either to the diversity of libraries or to the availability of focused libraries. ... -
Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces
(2003-01)We have investigated a series of molecular and polymeric approaches for generating adherent thin films that impart anti-fouling characteristics to oxide surfaces. These films incorporate oligo- or poly(ethylene glycol) ... -
NIR-Sensitive Au-Au₂S Nanoparticles for Drug Delivery
(2003-01)Near IR (NIR) sensitive Au-Au₂S nanoparticles were prepared by mixing HAuCl₄ and Na₂S in aqueous solutions. An anti-tumor drug, cis-platin, was adsorbed onto Au-Au₂S nanoparticle surface via the 11-mercaptoundecanoic acid ... -
Electrochemical Insertion/extraction of Lithium in Multiwall Carbon Nanotube/Sb and SnSb₀.₅ Nanocomposites
(2003-01)Multiwall carbon nanotubes (CNTs) were synthesized by catalytic chemical vapor deposition of acetylene and used as templates to prepare CNT-Sb and CNT-SnSb₀.₅ nanocomposites via the chemical reduction of SnCl₂ and SbCl₃ ... -
Smart Microgel Studies. Interaction of Polyether-Modified Poly(Acrylic Acid) Microgels with Anticancer Drugs
(2003-01)Studies of submillimeter gels composed of covalently cross-linked poly(acrylic acid)-g-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (Pluronic-PAA) networks are reviewed in light of potential applications ... -
Glycosylation by Chinese Hamster Ovary Cells in Dolichol Phosphate-Supplemented Cultures
(2003-01)N-linked glycosylation often imparts important properties to protein therapeutics. An essential step in this intracellular process is the transfer of oligosaccharide from dolichol monophosphate (Dol-P) to a potential ... -
Synthesis and Characterization of a Magnetically Responsive Polymeric Drug Delivery System
(2003-01)A magnetic target drug delivery system consisting of biodegradable polymeric microspheres (poly D, L-lactic acid) loaded with magnetite nanoparticles (10-100 nm) and anticancer drug (paclitaxel) was studied. The magnetite ... -
Designer peptides to understand the mineralization of calcium salts
(2003-01)Recently, we reported the extraction, purification and amino acid sequence of ansocalcin, the major goose eggshell matrix protein. In vitro studies showed that ansocalcin induces spherical calcite crystal aggregates. We ... -
Association Behavior of Poly(methacrylic acid)-block-Poly(methyl methacrylate) in Aqueous Medium: Potentiometric and Laser Light Scattering Studies
(2003-01)Atom transfer radical polymerisation (ATRP) technique was used to synthesize poly(methacrylic acid-block-methyl methacrylate) (P(MAA₁₀₂-b-MMA₁₀)) copolymer in order to study the aggregation behavior in aqueous solution ...
