Titration Microcalorimetry Study: Interaction of Drug and Ionic Microgel System

dc.contributor.author	Tian, Y.
dc.contributor.author	Tam, Michael K. C.
dc.contributor.author	Hatton, T. Alan
dc.contributor.author	Bromberg, Lev
dc.date.accessioned	2003-12-16T14:34:33Z
dc.date.available	2003-12-16T14:34:33Z
dc.date.issued	2004-01
dc.identifier.uri	http://hdl.handle.net/1721.1/3953
dc.description.abstract	Doxorubicin (DOX) and Pluronic-PAA interaction was investigated using isothermal titration calorimetry (ITC). DOX/polymer interaction is governed primarily by electrostatic interaction. The uptake of DOX results in the formation of insoluble polymer/DOX complex. Addition of salt weakens the interaction of drug and polymer by charge shielding effect between positive ionized amino group on DOX and oppositely charged polymer chains. However high drug-loading capacity in high salt condition implied that self-association property of DOX also play a role in the drug loading process.	en
dc.description.sponsorship	Singapore-MIT Alliance (SMA)	en
dc.format.extent	217967 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en_US
dc.relation.ispartofseries	Molecular Engineering of Biological and Chemical Systems (MEBCS);
dc.subject	anticancer drug	en
dc.subject	ionic microgel	en
dc.subject	electrostatic interaction	en
dc.subject	hydrophobic interaction	en
dc.title	Titration Microcalorimetry Study: Interaction of Drug and Ionic Microgel System	en
dc.type	Article	en