Synthesis and Properties of Novel Cationic, Temperature-Sensitive Block-Copolymers

Author(s)
Deshmukh, Smeet; Bromberg, Lev; Hatton, T. Alan
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Abstract
Facile, one-step synthesis of self-assembling, cationic block copolymers of poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and PEO-PPO-PEO (Pluronic®) is developed. The copolymers are obtained via free-radical polymerization of DMAEMA initiated by Pluronic-radicals generated by cerium (IV). The copolymers possess surface activity, are polycationic at pH<7.1, and self-assemble into micelle-like aggregates when neutralized. Potential applications of the novel copolymers for DNA transfection in gene therapy are discussed.
Date issued
2004-01
URI
http://hdl.handle.net/1721.1/3952
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Keywords
poly(2-N-(dimethylaminoethyl) methacrylate) Pluronic®, cerium (IV), free-radical polymerization, self-assembly, gene therapy
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