Synthesis and Properties of Novel Cationic, Temperature-Sensitive Block-Copolymers

dc.contributor.author	Deshmukh, Smeet
dc.contributor.author	Bromberg, Lev
dc.contributor.author	Hatton, T. Alan
dc.date.accessioned	2003-12-16T14:30:52Z
dc.date.available	2003-12-16T14:30:52Z
dc.date.issued	2004-01
dc.identifier.uri	http://hdl.handle.net/1721.1/3952
dc.description.abstract	Facile, one-step synthesis of self-assembling, cationic block copolymers of poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and PEO-PPO-PEO (Pluronic®) is developed. The copolymers are obtained via free-radical polymerization of DMAEMA initiated by Pluronic-radicals generated by cerium (IV). The copolymers possess surface activity, are polycationic at pH<7.1, and self-assemble into micelle-like aggregates when neutralized. Potential applications of the novel copolymers for DNA transfection in gene therapy are discussed.	en
dc.description.sponsorship	Singapore-MIT Alliance (SMA)	en
dc.format.extent	335893 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en_US
dc.relation.ispartofseries	Molecular Engineering of Biological and Chemical Systems (MEBCS);
dc.subject	poly(2-N-(dimethylaminoethyl) methacrylate) Pluronic®	en
dc.subject	cerium (IV)	en
dc.subject	free-radical polymerization	en
dc.subject	self-assembly	en
dc.subject	gene therapy	en
dc.title	Synthesis and Properties of Novel Cationic, Temperature-Sensitive Block-Copolymers	en
dc.type	Article	en